Job Description
Gate Bioscience is a venture-backed, preclinical biotech company creating a new class of medicines called Molecular Gates. Our therapeutics are small molecules that aim to cure diseases by selectively eliminating harmful extracellular proteins at their origin: inside the cell. Every extracellular protein—of which there are more than 4,000—must pass through a single channel in the cell before it can be secreted into the body. Molecular Gates bind to this channel, setting up a “gate” that recognizes and blocks a specific, disease-causing protein from exiting. With nowhere to go, the protein is degraded instead of being secreted. By eliminating the harmful protein at the source, Gate aims to eliminate the disease for patients. Founded in 2021, Gate is backed by Versant Ventures, a16z Bio + Health, ARCH Venture Partners, and GV. Learn more at
The Role:
The Computational Chemist will play a key role in developing optimization strategies for our most important drug discovery campaigns. This role will review experimental results and develop SAR hypotheses for activity, selectivity and properties, and make suggestions to improve the profiles of our leading molecules. In addition, the ideal candidate will work closely with biochemistry, structural biology and functional genomics to bring insights from protein-protein and protein small molecule modeling to further enhance our understanding of the novel mechanism of molecular gates. This role will provide leadership and strategic opportunities via target selection, experimental design, developing and enhancing our chemical library, managing external resources, and mentoring junior scientists. As an integral member of our team, this candidate will work closely with other scientists on drug discovery and pre-clinical projects from a computational perspective.
In this role you will:
What to expect if you join us:
In the first month, you will work closely with our scientists to gain understanding of internal drug discovery and pre-clinical programs and begin to define best practices from a computational perspective.
By three months, you begin to review experimental results and analyze datasets to build expertise as you begin to develop modeling initiatives geared toward chemical diversity expansion and mechanism of action.
By six months, you will begin to provide suggestions on how to improve the profiles of our leading projects and to provide insights into the molecular mechanism of action.
Preferred Education and Experience:
Compensation:
Below is the expected salary range for this position. Individual compensation is based on various factors, including level, experience, education, skill set, and geographic location. This range is for our San Francisco Bay Area, location and may be adjusted to the labor market in other geographic areas. Target Salary Range: $170,000 - $270,000.
In addition to salary, Gate Bioscience offers equity in the company, a robust benefits package, 401(k) program with employer match, and the opportunity to be a part of ground-breaking research.
Gate Bioscience is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, or gender identity, national origin, disability, or veteran status.
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